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Histofreezer

Portable Cryosurgical System

The Histofreezer® Portable Cryosurgical System is a professional-grade product that offers medical professionals an easy and effective method to treat nine different types of skin lesions, including common, plantar, and genital warts and other common benign skin lesions. More than 60,000 medical professionals in primary care, internal medicine, podiatry, ob/gyn and dermatology areas of care have either added Histofreezer® to their practice offering or replaced more invasive and less tolerated procedures with the Histofreezer® advantage.

How To Use

Histofreezer® is user-friendly and requires just one hand to perform the procedure. It’s as easy as 1 – 2 – 3.

Charge

Charge the applicator by pressing the valve until droplets start to form.

Invert

Invert the canister for 15 seconds to achieve optimal freezing temperature.

Apply

Apply the frozen applicator to lesion for 15-40 seconds*

*See package insert for indications treatment time

Sample Kit

Receive a free sample kit*

  • *US Only

REIMBURSEMENT

EXPAND YOUR PATIENT SERVICES

RETAIN TREATMENT REIMBURSEMENTS WITHIN YOUR PRACTICE

MINIMIZE PATIENT REFERRALS WHILE MAXIMIZING PRACTICE RESOURCES

THE HISTOFREEZER SYSTEM® IS FDA-CLEARED FOR 9 INDICATIONS AND IS RECOGNIZED BY MEDICARE, MEDICAID AND MAJOR INSURANCE CARRIERS.1,2

1) CMS, Physician Free Schedule accessed at: http://www.cms.gov/Medicare/Medicare-Fee-for-Service-Payment/PhysicianFeeSched/index.html?redirect=/physicianfeesched/#

2) Histofreezer® Portable Cryosurgical System Directions for Use.

FAQS

The following are frequently asked questions about the Histofreezer Portable Cryosurgical System from CryoConcepts LP., a product only available to the professional market. For additional information, please contact Customer Care.

The Histofreezer products are only sold through Medical/Surgical distributors. Please contact our Customer Care Department (support@cryoconcepts.com) for help locating an authorized distributor in your area.

60M2C+10 VALUE KIT

Histofreezer 60M2C+10 Value Kit
  • 70-140 applications per kit*
  • (24) 2mm and (46) 5mm applicators
  • Up to three-year shelf-life
  • Ideal for high volume practices

36M1C STARTER KIT

Histofreezer 36M1C Kit
  • 36-72 applications per kit*
  • (12) 2mm and (24) 5mm applicators
  • Up to three-year shelf-life
  • Ideal for small and large lesions

36F1C 5MM SPECIALTY KIT

Histofreezer 36F1C Kit
  • 36-72 applications per kit*
  • (36) 5mm applicators
  • Up to three-year shelf-life
  • Ideal for treatment of larger lesions and plantar warts

40T1C 2MM SPECIALTY KIT

Histofreezer 40T1C Kit
  • 40-80 applications per kit*
  • (40) 2mm applicators
  • Up to three-year shelf-life
  • Ideal for treatment of smaller lesions

*See  Package Insert for more information

Verruca vulgaris (Common warts)
A common wart of the skin or mucosa. The warts are round firm skin-colored papules with a hyperkeratotic (thickening) papillary surface. Sizes range between 1 to 10 mm. The hands, fingers and knees are common sites. Thrombosed capillaries which appear as black dots can be seen on the surface of some warts.
Verruca plantaris (Plantar warts)
Painful, unappealing benign tumors on the sole of the feet caused by the Human Papillomavirus (HPV-1) when it enters the skin through a cut or skin erosion. These warts can generally be characterized as rough, round-oval growths that can be lighter or darker than their surroundings.
Verruca plana
Also known as a “flat wart”, round or oval shaped, only slightly elevated and sharply defined. They may induce however significant disturbances of pigmentation anywhere from flesh-colored in appearance to dark brown. Auto inoculation by scratching can result in linearly grouped lesions. Location of these lesions is commonly found on the forehead, cheeks, perioral (tissues around the mouth) as well as the dorsal side of hands and arms.
Molluscum contagiosum
A contagious disease of the skin caused by intranuclear proliferation of a virus of the family Poxviridae and characterized by the appearance of small,pearly, umbilicated papular epidermal growths. In adults it typically occurs on or near the genitals and is sexually transmitted.
Acrochordon
Common benign skin growths (a/k/a skin tags) that occur most often after midlife. They are tiny skin protrusions, and may have a small narrow stalk connecting the skin bump to the surface of the skin. The origin is unknown however is believed to be an inherited indication.
Actinic keratosis
A premalignant warty lesion occurring on the sun-exposed skin of the face or hands in aged light-skinned persons; hyperkeratosis may form a cutaneous horn, and squamous cell carcinoma of low-grade malignancy may develop in a small proportion of untreated patients.
Lentigo
A brown macule resembling a freckle except that the border is usually regular, and microscopic proliferation of rete ridges is present; scattered melanocytes are seen in the basal cell layer.
Seborrheic keratosis
Superficial, benign, verrucous, often pigmented, greasy lesions consisting of proliferating epidermal cells, resembling basal cells,enclosing horn cysts; they usually occur after the third decade.
Condyloma acuminata
A warty growth on the external genitals or at the anus, consisting of fibrous overgrowths covered by thickened epithelium showing koilocytosis,due to sexually transmitted infection with human papilloma virus; malignant change is associated with particular types of the virus.

Note: Refer to the Histofreezer  Package Insert for the lesion-specific treatment times.

Lesions are resolved in one to four treatments with two-week intervals between treatments.

The Histofreezer products have a shelf life of three years from the date of manufacture. Though the need is unlikely, this means there is sufficient cryogen in each canister on the expiration date to saturate all of the Histofreezer applicators provided in a kit.

A study showed an average rate of 93.4% effectiveness for a variety of lesions.1

After saturation of a 5mm Histofreezer applicator, you may perform a second application on the same patient after a 15-second pause between applications. The use time of a saturated 5mm Histofreezer applicator is 120 seconds.

After saturation of a 2mm Histofreezer applicator, you may perform a second application on the same patient after a 15-second pause between applications.The use time of a saturated 2mm Histofreezer applicator is 90 seconds.

Note: Refer to the Histofreezer  Package Insert for the lesion-specific treatment times.

Hold the canister in the upright position. Charge the bud until droplets form. Stop charging, invert the canister with the bud pointing to the floor and wait 15 seconds before treating the lesion.  Click Here to View Histofreezer Demonstration Video

The applicator temperature reaches -55°C, which minimizes risk of scarring or blistering of the treatment site.

Do not use a used applicator for another patient due to risk of cross-contamination. A sufficient supply of applicators is included with each kit.

No. Histofreezer has been approved for external condyloma lesions only. This would include any condyloma for anogenital, labial and penile lesions.

The Dimethyl Ether, Propane, and Isobutane gas in the Histofreezer canister is a clear liquefied gas that is not harmful to clothing or furniture. Any drips that occur can be simply washed off with a mild soap and will not leave any stains.

INSTRUCTIONS FOR USE

International

ENGLISH

ESTONIAN

FINNISH

FRENCH

GERMAN

HUNGARIAN

INDONESIAN

ITALIAN

LATVIAN

LITHUANIAN

MALAYSIAN

NORWEGIAN

POLISH

PORTUGUSE

ROMANIAN

RUSSIAN

SLOVAK

SLOVENE

SPANISH

SWEDISH

TURKISH

UKRANIAN

CLINICAL INDICATIONS

Acrochordon (Skin Tags)

Actinic Keratosis (Facial)

Actinic Keratosis (Non-Facial)

Condyloma Acuminata (Genital Warts)

Lentigo (Facial)

Lentigo (Non-Facial)

Molluscum Contagiosum (MCV)

Seborrheic Keratosis

Verruca Plana (Flat Warts)

Verruca Vulgaris (Common Warts)

PERFORMANCE

Histofreezer® has proven clinical performance.

Histofreezer demonstrated comparable results when compared to liquid nitrogen

CLINICAL INDICATIONS

Acrochordon (Skin Tags)

40 seconds

Actinic Keratosis (Facial)

15 seconds

Actinic Keratosis (Non-Facial)

40 seconds

Condyloma Acuminata (Genital Warts)

40 seconds

Lentigo (Facial)

15 seconds

Lentigo (Non-Facial)

40 seconds

Molluscum Contagiosum (MCV)

20 seconds

Seborrheic Keratosis

40 seconds

Verruca Plana (Flat Warts)

20 seconds

Verruca Vulgaris (Common Warts)

20 seconds

Verruca Plantaris (Plantar Warts)

40 seconds

Verruca Vulgaris (Common Warts)

40 seconds

INTERNATIONAL DISTRIBUTORS

EBOS Group Pty Ltd. | Australia



Advanced Medical Technology | Lebanon, Qatar, Kingdom of Bahrain, United Arab Emirates, Libya



Hospithera SA  | Belgium



Nimotech s.r.o.  |  Czech



Triolab AS  |  Denmark and Iceland



Skafte Medlab  |  Finland



France Collectivites  |  France, French Overseas Departments & Territories (DOM & TOM), Malta, Monaco, Tunisia, Algeria and Morocco



BSN Medical  |  Germany and Austria



Health Life Technology Medicine (HLTM) |  Greece and Cypress



PROMED  |  Republic of Ireland



GIMA S.p.A.  |  Italy



PROMEVET  |  Italy



Salam Healthcare Supplies |  Malaysia



Daxtrio  |  Netherlands



LEFROSCH Sp. z o.o.  |  Poland



Chemomed Intertrading SRL  |  Romania



Quirumed  |  Spain, Andorra and Portugal



TT Pharma s.r.o.  |  Slovak Republic



Dr. Gorkic Ltd.  |  Slovenia



BSN Medical Distribution Ltd.  |  South Africa, Lesotho, Swaziland, Botswana, Namibia, Zimbabwe, Mozambique



Skafte Medlab  |  Sweden, Norway



Delpharm SARL  |  Switzerland and Lichtenstein



Thai Care  |  Thailand, Laos, Cambodia, and Myanmar



Leofarma Co. Ltd.  |  Turkey



Galen Limited  |  United Kingdom, Northern Ireland, Isle of Mann, Channel Islands

ABC Medical Inc. | 800-361-3558  |  Canada

Barik Medical Inc. | 800-265-6061  |  Canada

Canada Medical Ltd. | 800-232-7286  |  Canada

Dufort Et Lavigne Ltee | 800-361-0655  |  Canada

Futuremed Healthcare Products L.P. | 800-387-7025  |  Canada

Henry Schein Arcona Inc. | 888-533-3032  |  Canada

Maxim Medical Supplies | 888-229-46332  |  Canada

Medi Gas | 866-446-6302  |  Canada

Medical Mart | 800-268-2848  |  Canada

Medical Mart West | 866-444-5848  |  Canada

Medi Select | 800-463-5166  |  Canada

MSS Medical & Surgical Supplies | 888-397-0886  |  Canada

MM Trading Group | 800-376-3164  |  Canada

Northern Medical Supplies Inc. | 888-842-9462  |  Canada

Northern Surgical & Medical | 800-461-1129  |  Canada

Nu-Life Medical & Surgical Supplies Inc. | 888-988-1555  |  Canada

Ontario Medical Supply | 800-267-1069  |  Canada

Pacific Health Care Supply Ltd. | 800-663-1194  |  Canada

Paladin Labs | 866-340-1112  |  Canada

Polymed Chirugical Inc. | 866-361-9840  |  Canada

Praxxair Distribution Inc. | 866-446-6302  |  Canada

Premier Medical Supply | 888-261-3513  |  Canada

Pro-Medix Inc. | 800-565-0765  |  Canada

Schaan Health Care Products | 800-667-3786  |  Canada

Shoppers Home Healthcare Medical Supply Division | 877-245-7746  |  Canada

Shoppers Home Stat Healthcare | 800-567-6001  |  Canada

Superior Medical Limited | 800-268-7944  |  Canada

Surgo Surgical Supply | 800-263-7402  |  Canada

The Stevens Company Limited | 800-268-0184  |  Canada

Valuemed Professional Products Ltd. | 800-919-8444  |  Canada

If you are a current Histofreezer distributor and would like your information listed on our website, please contact us at support@cryoconcepts.com.

Please fill out the form to receive your free sample kit